PureFocus850 Laser Autofocus System

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PureFocus850 is a revolutionary laser autofocus for biological and industrial imaging.

Prior Scientific’s PureFocus850 combines advanced optics and intelligent in-built microprocessing to provide a real time focus system for infinity corrected optical systems. A motorized offset lens allows real-time adjustment of the imaging depth into the sample, continuously holding the precise distance between imaging focal point and a reference boundary of choice.

The PureFocus850 is easily adaptable to any optical system, it is suitable to both upright and inverted microscopes. The patent pending PureFocus850 system allows powerful automated autofocus functionality to be added to existing microscope systems by installing the unit into the infinity space (between objective and tube lens). The PureFocus850 is an integrated unit comprising of an IR laser diode, precision optical components, detector and signal processing electronics with on-board micro controller. Outputs directly drive a step motor or provides output for servo or Piezo drives.

With the ability to autofocus on different interfaces including slides, glass bottom dishes, flow chambers and many more.

Key features of the PureFocus850

• Stepper motor and analog servo and Piezo outputs all available from one controller
• 1 millisecond response time (typical)
• Simple dichroic adjustment for easy install
• Easily adapted to any infinity optical system
• 850 nanometer laser minimizes impact for fluorescence microscopy
• Software setup and control GUI provided
• Stores multiple objective parameters for single and multi-objective use


High speed – 1ms typical response time
Software setup program provided
Simple dichroic adjustment for easy install
850 nanometer diode laser
Integrated stepper motor driver and interface to Piezo and other actuators via 0-10V analogue output
Configurable for multiple objectives and sample types
Compensates for microscope drift
Works with both upright & inverted optical systems


Fast and easy to setup system and start focusing
Easy to mount in infinity path
No color shift; outside the visible light range
Outside the emission of most fluorophores
Works with your existing optical system
Easy to change parameters via PC command or keypad
Market leading system to reliably focus on slides and well plates
Maintain in focus images for long term studies

PureFocus850 Materials example PureFocus850 Semiconductor example
Ink Jet
Razor blade
Reflective Optics
Photovoltaic (PV)
Diamond Fly Cutting
Cell Culture
Confocal Imaging
Neuroscience Imaging
Fluorescence imaging
Cytology & Pathology
Well plates & Slides
Routine Microscopy
Data Storage
Semiconductor Wafers
Micro-Electro-Mechanical Systems (MEMS)
Laser Ablation
Other automated inspection and vision based applications