{"id":5105,"date":"2017-10-17T12:00:00","date_gmt":"2017-10-17T12:00:00","guid":{"rendered":"https:\/\/gk5l0g06kd.onrocket.site\/news\/fluorescent-tags-and-nanoparticles-compared-as-biological-imaging-tools-using-prior-stage\/"},"modified":"2026-09-12T12:31:05","modified_gmt":"2026-09-12T12:31:05","slug":"fluorescent-tags-and-nanoparticles-compared-as-biological-imaging-tools-using-prior-stage","status":"publish","type":"news","link":"https:\/\/www.prior.com\/us\/news\/fluorescent-tags-and-nanoparticles-compared-as-biological-imaging-tools-using-prior-stage\/","title":{"rendered":"Fluorescent tags and Nanoparticles compared as biological imaging tools using Prior stage"},"content":{"rendered":"<div class=\"yoast-breadcrumbs\"><span><span><a href=\"https:\/\/www.prior.com\/us\/\">Home<\/a><\/span> \u00bb <span><a href=\"https:\/\/www.prior.com\/us\/news\/\">News<\/a><\/span> \u00bb <span class=\"breadcrumb_last\" aria-current=\"page\">Fluorescent tags and Nanoparticles compared as biological imaging tools using Prior stage<\/span><\/span><\/div>\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n\n<h1 class=\"wp-block-heading\">Fluorescent tags and Nanoparticles compared as biological imaging tools using Prior stage<\/h1>\n\n\n\n<p class=\"wp-block-post-date wp-block-paragraph\">17.10.17<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A Prior stage has been used in a ground-breaking study comparing traditional fluorescent tags to Surface Enhanced Raman Scattering Nanoparticles (SERS NPs), which found there were significant differences between the two imaging methods.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Prior Scientific&rsquo;s H117 motorized precision stage was used in a study comparing the characteristics of traditional fluorescent probes with SERS NPs, in which the two methods were used to fluorescently image both live and fixed cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Interest in using SERS NPs rather than traditional fluorescent tags in biological imaging is growing, due to the nanoparticles&rsquo; stability and the narrow spectral features that they display. Maria Navas-Moreno and colleagues at the University of California Davis Centre for Biophotonics compared fluorescent probes and SERS NPs, showing that the two methods produced similar results in fixed cells, but dramatically different patterns when used on live cells. This research, published in Scientific Reports, demonstrates that unexpected cellular interactions with nanoparticles must be taken into account, before using SERS as an alternative to traditional probes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A home-built Raman microscopy system, incorporating an H117 stage, was a key part of this system. Especially important from Maria&rsquo;s view was that the H117&rsquo;s large travel range (114 x 75 mm) ensured that a large field of view was easy to image. Manuj Patel, Global Strategic Marketing Manager for Prior Scientific, says:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&ldquo;The H117 stage is frequently the stage of choice for live cell imaging, as it offers a combination of speed, easy &nbsp;integration into numerous imaging packages via the ProScan III control system, and precision positioning, with a repeatability of &nbsp;just 0.2 um, and a metric accuracy of 0.059 um\/mm. &nbsp;I&rsquo;m very grateful to Maria and her colleagues for sharing their interesting research with us, as well as providing such positive feedback on our products.&rdquo;<\/p>\n\n<\/div>\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"704\" height=\"540\" src=\"https:\/\/www.prior.com\/wp-content\/uploads\/2023\/05\/Priorlogoresizedforblogsnews704x540.png\" alt=\"Green and Black Prior Scientific Logo.\" class=\"wp-image-4395\" srcset=\"https:\/\/www.prior.com\/wp-content\/uploads\/2023\/05\/Priorlogoresizedforblogsnews704x540.png 704w, https:\/\/www.prior.com\/wp-content\/uploads\/2023\/05\/Priorlogoresizedforblogsnews704x540-300x230.png 300w\" sizes=\"(max-width: 704px) 100vw, 704px\" \/><\/figure>\n<\/div><\/div>\n\n\n<div class=\"wp-block-group alignfull has-background\" style=\"background-color:#f5f5f5;padding-top:70px;padding-right:4%;padding-bottom:70px;padding-left:4%\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-container-core-group-is-layout-7a0b55d5 wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-center\">More News<\/h2>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><a href=\"\/us\/news\/new-led-system-for-fluorescence-microscopy\/\"><img decoding=\"async\" width=\"704\" height=\"540\" src=\"https:\/\/www.prior.com\/wp-content\/uploads\/2026\/09\/news-01-07-2012-704x540-1.jpg\" alt=\"New LED System for Fluorescence Microscopy\" class=\"wp-image-10020\" srcset=\"https:\/\/www.prior.com\/wp-content\/uploads\/2026\/09\/news-01-07-2012-704x540-1.jpg 704w, https:\/\/www.prior.com\/wp-content\/uploads\/2026\/09\/news-01-07-2012-704x540-1-300x230.jpg 300w\" sizes=\"(max-width: 704px) 100vw, 704px\" \/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">01.07.12<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-medium-font-size\"><a href=\"\/us\/news\/new-led-system-for-fluorescence-microscopy\/\">New LED System for Fluorescence Microscopy<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"\/us\/news\/new-led-system-for-fluorescence-microscopy\/\"><strong>Learn More<\/strong><\/a><\/p>\n<\/div>\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><a href=\"\/us\/news\/h101f-flat-top-stage\/\"><img decoding=\"async\" width=\"704\" height=\"540\" src=\"https:\/\/www.prior.com\/wp-content\/uploads\/2026\/09\/news-01-05-2013-704x540-1.jpg\" alt=\"H101F Flat Top Stage\" class=\"wp-image-10021\" srcset=\"https:\/\/www.prior.com\/wp-content\/uploads\/2026\/09\/news-01-05-2013-704x540-1.jpg 704w, https:\/\/www.prior.com\/wp-content\/uploads\/2026\/09\/news-01-05-2013-704x540-1-300x230.jpg 300w\" sizes=\"(max-width: 704px) 100vw, 704px\" \/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">01.05.13<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-medium-font-size\"><a href=\"\/us\/news\/h101f-flat-top-stage\/\">H101F Flat Top Stage<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"\/us\/news\/h101f-flat-top-stage\/\"><strong>Learn More<\/strong><\/a><\/p>\n<\/div>\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><a href=\"\/us\/news\/optimize-z-stack-image-acquisition-speed-using-proscan-iii-ttl-breakout-box-h31ttlbb\/\"><img decoding=\"async\" width=\"704\" height=\"540\" src=\"https:\/\/www.prior.com\/wp-content\/uploads\/2026\/09\/news-05-01-2014-704X540.jpg\" alt=\"Optimize Z Stack Image Acquisition Speed Using ProScan III TTL Breakout Box (H31TTLBB)\" class=\"wp-image-10018\" srcset=\"https:\/\/www.prior.com\/wp-content\/uploads\/2026\/09\/news-05-01-2014-704X540.jpg 704w, https:\/\/www.prior.com\/wp-content\/uploads\/2026\/09\/news-05-01-2014-704X540-300x230.jpg 300w\" sizes=\"(max-width: 704px) 100vw, 704px\" \/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">05.01.14<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-medium-font-size\"><a href=\"\/us\/news\/optimize-z-stack-image-acquisition-speed-using-proscan-iii-ttl-breakout-box-h31ttlbb\/\">Optimize Z Stack Image Acquisition Speed Using ProScan III TTL Breakout Box (H31TTLBB)<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"\/us\/news\/optimize-z-stack-image-acquisition-speed-using-proscan-iii-ttl-breakout-box-h31ttlbb\/\"><strong>Learn More<\/strong><\/a><\/p>\n<\/div>\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><a href=\"\/us\/news\/introducing-the-ldb100f-brightfield-led-illumination-system\/\"><img decoding=\"async\" width=\"704\" height=\"540\" src=\"https:\/\/www.prior.com\/wp-content\/uploads\/2026\/09\/news-14-02-2014-704X540.jpg\" alt=\"Introducing the LDB100F Brightfield LED Illumination System\" class=\"wp-image-10015\" srcset=\"https:\/\/www.prior.com\/wp-content\/uploads\/2026\/09\/news-14-02-2014-704X540.jpg 704w, https:\/\/www.prior.com\/wp-content\/uploads\/2026\/09\/news-14-02-2014-704X540-300x230.jpg 300w\" sizes=\"(max-width: 704px) 100vw, 704px\" \/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">14.02.14<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-medium-font-size\"><a href=\"\/us\/news\/introducing-the-ldb100f-brightfield-led-illumination-system\/\">Introducing the LDB100F Brightfield LED Illumination System<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"\/us\/news\/introducing-the-ldb100f-brightfield-led-illumination-system\/\"><strong>Learn More<\/strong><\/a><\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>A Prior stage has been used in a ground-breaking study comparing traditional fluorescent tags to Surface Enhanced Raman Scattering Nanoparticles (SERS NPs), which found there were significant differences between the two imaging methods.<\/p>\n","protected":false},"featured_media":4395,"template":"","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"class_list":["post-5105","news","type-news","status-publish","has-post-thumbnail","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Fluorescent tags and Nanoparticles compared as biological imaging tools using Prior stage | PriorScientific<\/title>\n<meta name=\"description\" content=\"A Prior stage has been used in a ground-breaking study comparing traditional fluorescent tags to Surface Enhanced Raman Scattering Nanoparticles...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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